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The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews

Our review highlights the need for large, high quality trials to reduce uncertainty about the efficacy of paracetamol for relieving common pain conditions. Available evidence is largely derived from trials that evaluated the effects of single doses; investigations of multiple dose regimens, reflecting usual practice, are needed. For some long term conditions, such as osteoarthritis, long term efficacy and safety should also be evaluated.

While paracetamol is widely used, its efficacy in relieving pain has been established for only a handful of conditions, and its benefits are often modest. Although some trials have evaluated regimens that may have underestimated its utility, the clinical application of paracetamol is primarily guided by low quality evidence, at best.

#science #chiropractor #chiropractic #research #education #evidence based #patient centered #interprofessional #collaborative #rehabilitation #public health #spinal health #musculoskeletal health #ethics #pain #function #disability #QOL #knowledgetranslation        

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